Epigenetics - from mechanisms to disease

Epigenetics - from mechanisms to disease

April 18-22, 2016
ICVS/ECS-UMinho
Epigenetics - from mechanisms to disease

April 18-22, 2016
ICVS/ECS-UMinho
Epigenetics - from mechanisms to disease

April 18-22, 2016
ICVS/ECS-UMinho

Scope
Organization
Faculty
Programme
Bibliography
Evaluation
Registration

Scope

One major challenge in biology is to understand how epigenetic modifications contribute to transcriptional plasticity. This issue is of particular importance in the brain, where experience-dependent changes in gene transcription are essential for its normal activity. Indeed, loss-of-function of key epigenetic regulators is associated with the development of disease-related symptomatology.

The main topics that will be covered in this course are:
- Understand the role of epigenetic regulators in the control of gene expression and cellular identity;
- Understand DNA methylation/hydroxymethylation changes to explain differential expression and characterize gene-specific histone modifications, both permissive and repressive;
- Understand the impact of epigenetic modifications in several mechanisms and diseases.

The course will be mainly theoretical but practical approaches for analysing epigenetic modifications will also be addressed.

This course does not provide credentials for the exercise of medicine for those without appropriate training, recognition and registered at the "Ordem dos Médicos".

Organization

Joana Marques
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Luísa Pinto
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Faculty

Ana João Rodrigues
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Ana Luisa Cardoso
Center for Neuroscience and Cell Biology (CNC)
Coimbra, Portugal

Bruno Costa
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Carla Oliveira
i3S - Instituto de Investigação e Inovação em Saúde / IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto
Porto, Portugal

Carmen Jerónimo
Instituto Português de Oncologia
Porto, Portugal

Filipe Pereira
Center for Neuroscience and Cell Biology (CNC) / UC-Biotech
Coimbra, Portugal

Hans Van Bokhoven
Radbound University Medical Center
Nijmegen, Netherlands

Joana Marques
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Lars Jansen
Instituto Gulbenkian de Ciência
Lisbon, Portugal

Luísa Pinto
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Marta Viana-Pereira
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Miguel Branco
Blizard Institute
London, UK

Orborne Almeida
Max Planck Institute
Munich, Germany

Patrícia Maciel
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
Braga, Portugal

Philippe Arnaud
Clermont-Ferrand Université
Clermont-Ferrand, France

Rui Martinho
Centre for Biomedical Research (CBMR)
Faro, Portugal

Sérgio Almeida
Instituto de Medicina Molecular
Lisbon, Portugal

Simão Teixeira da Rocha
Instituto de Medicina Molecular
Lisbon, Portugal

Vasco Barreto
Instituto Gulbenkian de Ciência
Lisbon, Portugal

Programme

This course will be held from April 18th to 22nd 2016 but internal MSc and PhD program students will have an extra week (April 26-29, 2016). Click here to download the programme

Monday, April 18th 2016 ::: Introduction and Epigenetics in Neuroscience

09:15 - 09:30	Registration at the ICVS/ECS hall
09:30 - 09:45	Introduction and Objectives [Luísa Pinto]
09:45 - 10:30	T1: Introduction to Epigenetics [Joana Marques]
10:30 - 11:00	Coffee-break
11:00 - 11:30	T2: Methodologies to study Epigenetics [Joana Marques]
11:30 - 13:00	Lunch
13:00 - 14:00	"Ciência Falada" - Gonçalo Castelo-Branco (Karolinska Institute)
14:00 - 15:00	T3: MiRNA deregulation in dementia: epigenetic tools, biomarkers and therapeutic targets [Ana Luísa Cardoso]
15:00 - 16:00	T4: Stress and the reward circuit: from genes to neurons to behaviour [Ana João Rodrigues]
16:00 - 16:30	Coffee-break
16:30 - 18:00	T5: Epigenetic factors that modulate neuro- and glio-plasticity in depression [Luísa Pinto]

Tuesday, April 19th 2016 ::: Epigenetics in Cancer

09:30 - 10:45	T6: Genetic and epigenetic players in brain tumors: mechanistic and prognostic insights [Bruno Costa]
10:45 - 11:15	Coffee-break
11:15 - 12:00	T7: Deciphering the role of the tumor suppressor gene SPINT2 in solid tumors [Marta Viana-Pereira]
12:30 - 14:00	Lunch
14:00 - 15:45	T8: MiRNAs deregulation in Prostate cancer [Carmen Jerónimo]
15:45 - 16:15	Coffee-break
16:15 - 18:00	T9: Epigenetic mechanisms of gene expression regulation in gastric cancer [Carla Oliveira]

Wednesday, April 20th 2016 ::: Epigenetics in Developmental Biology

10:30 - 10:45	T10: Epigenetic regulation of neural differentiation [Joana Marques]
10:45 - 11:15	Coffee break
11:15 - 12:30	T11: Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodeling [Rui Martinho]
12:30 - 14:00	Lunch
14:00 - 15:45	T12: Safeguarding the integrity of genetic information [Sérgio Almeida]
15:45 - 16:15	Coffee break
16:15 - 18:00	TT13: Principles of epigenetic inheritance [Lars Jansen]

Thursday, April 21st 2016 ::: Genomic Imprinting / Epigenetics in Intellectual Disabilities

09:30 - 12:30	T14: Genomic Imprinting in mammals [Philippe Arnaud]
12:30 - 14:00	Lunch
14:00 - 15:30	T15: X-Chromosome inactivation [Simão Teixeira da Rocha]
15:30 - 16:00	Coffee break
16:00 - 18:00	T16: Genomic imprinting and Assisted Reproduction Techniques [Joana Marques]

Friday, April 22nd 2016 ::: Epigenetics, Reprogramming and Cellular Memory

09:30 - 10:30	T17: The genetics of epigenetics in neurodevelopmental disorders [Patrícia Maciel]
10:30 - 11:00	Coffee break
11:00 - 12:00	T18: Programming Definitive Hematopoiesis [Filipe Pereira]
12:00 - 13:00	Lunch
13:00 - 14:30	T19: SEMINAR ::: Epigenetic mechanisms in preimplantation development [Miguel Branco]
14:30 - 15:00	Scientific discussion with Seminar Presenter
15:00 - 16:00	T20: The mystique of Epigenetics [Vasco Barreto]
16:00 - 16:30	Coffee break
16:30 - 17:30	T21: Programming Mental Healthspan [Osborne Almeida]
17:30 - 18:00	Final Remarks/ Quizz

April 26th to 29th 2016 ::: Only for internal MSc and PhD program students

All day

Individual/Tutorial training

Bibliography

The following books are recommended:

- The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance.
   Author: Nessa Carey. Columbia University Press. ISBN-10: 0231161174.
- The Handbook of Epigenetics: The New Molecular and Medical Genetics.
   Editor: T Tollefsbol. Elsevier Academic Press. ISBN-9780123757098.
- Epigenetic Regulation in the Nervous System: Basic mechanisms and clinical impact.
   Editors: Sweatt, Meaney, Nestler and Akbarian. Elsevier Academic Press. ISBN- 9780123914941.

Evaluation

The evaluation methodology* is available here (in Portuguese only).

*The evaluation is mandatory for students enrolled in the MSc and PhD programs of the School of Health Sciences and optional for the other participants.

Registration

To register, please fill out the registration form. Within 48/72h, we will send you the confirmation and details for the payment. Please contact us if you do not receive a response in the next 5 days.

Maximum number of participants: 30

Registration deadline: April 11th 2016
Fees until March 20th 2016: 150 EUR for master and PhD students / 250 EUR for other participants

The fee includes all the necessary material for the course, coffee-breaks and certificate of attendance.

Click here to access the online form and further details for the registration

EDUCATIONAL SUPPORT

Scope

Organization

Faculty

Programme

Bibliography

Evaluation

Registration

Information

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