- Identify the organization of the body’s defenses against pathogens: from innate to adaptive immunity. - Describe the ontogeny of cells of the innate and acquired immune system, their relevance and how they interact during an immune response. - Understand how the immune system senses danger and how that initiates an immune response. - Recognize the immune system’s antimicrobial mechanisms: from toxic intermediate to cell death. - Identify the major T cell phenotypes, the cytokines and transcription factors required for their differentiation and function. - Recognize the importance of the metabolic choices of different immune cell subsets - Recognize the impact of the microenvironment in T cell function. - Identify Mendelian and complex susceptibility to infectious diseases. - Define strategies for genome variation analyses.
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