Neurodegenerative diseases (NDD) are mechanistically complex and present a clinical challenge. During the last decades, it became clear that a variety of pathophysiological mechanisms are common to different NDD, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), prompting the need for studying them in an integrated fashion. However, many of the existent postgraduation courses focus to specific neurodegenerative diseases. Thus, this course “Pathogenesis of Neurodegenerative Diseases: finding a common ground” explores the commonalities between conditions, with a NDD profile, that are normally considered separately.

The first part of the course will be dedicated to common, overlapping mechanisms found in several neurodegenerative conditions such as imbalance proteostasis (e.g. protein degradation/aggregation), inflammation, RNA dyshomeostasis (e.g. Stress granules), metabolic stress (e.g. mitochondria failure/oxidative stress), cell-to-cell communication/disease propagation (e.g. exosomes), (Wallerian) degeneration and lipid signalling/metabolism. The second part of the course will include clinical and neuropathological presentations followed by current/innovative therapeutic interventions for specific diseases/clinical entities – such as AD, PD, polyglutamine (poly Q) diseases, multiple sclerosis, neuropathic pain, prion diseases.

Aiming to bridge across fields of neurodegenerative pathologies, this course will bring together faculty with expertise in molecular, pathological and clinical standpoints of neurodegeneration related to prion, Tau and Abeta (AD), a-synuclein (PD), ataxin-3 (MJD), huntingtin (HD) and other proteins. 20 faculty members from USA and Europe with heterogeneous backgrounds will cover all basic and clinical themes to be presented. A significant amount of time has been therefore scheduled to maximize interactions between participants and faculty. Emphasizing on the triplet “Mechanisms-Clinical Pathology-Therapeutic Interventions”, this course is intended to MD/PhD students, Master and PhD students, post-doc researchers, residents and physicians with interest in neurodegenerative disorders and their clinical & molecular commonalities.

This course does not provide credentials for the exercise of medicine for those without appropriate training, recognition and registered at the "Ordem dos Médicos".​